Category Archives: Ideas

Designing Opioid-TRIs for Chronic Pain

Posted on January 18, 2010 by pharmaheretic

Another product of the patented mediocrity machine. Enjoy! The idea here is a new class of drugs to treat moderate to severe pain, without causing excess sedation and elevating mood. I have skipped representations of chirality, as it makes it … Continue reading →

Posted in Drug Space, Golden Age, Ideas, Legal Bullshit, Pharmacophores, Pseudo-Innovation, Serendipity | Leave a comment

Subject of Next Post: Poll

Posted on January 18, 2010 by pharmaheretic

I will write on all three, but your input will help me decide on the order of writing. As you probably understand, these posts cannot be edited within a few hours, though I have written up most of the material. … Continue reading →

Posted in Golden Age, Ideas, Legal Bullshit, Pseudo-Innovation | Leave a comment

The Mediocrity Machine

Posted on January 11, 2010 by pharmaheretic

The Patented Mediocrity Machine is my brain coming up with new ideas, when I am bored. I have two kinds of ideas: The truly original ideas that do not come often (and will not write on this blog) and Mediocre … Continue reading →

Posted in Dilbertisms, Drug Space, Golden Age, Heresy, Ideas, Legal Bullshit, MBA Madness, Pharmacophores, Pseudo-Innovation | Leave a comment

Designing TRIs: Adventures in Mediocrity

Posted on January 10, 2010 by pharmaheretic

I had a look at the pharmacophore requirements of Triple Reuptake Inhibitors (TRIs) and thought that some older drugs could be spruced up to act as TRIs. The reasons why I do this are here. Tranylcypromine is an old monoamine … Continue reading →

Posted in Drug Space, Golden Age, Ideas, Legal Bullshit, Pharmacophores, Pseudo-Innovation | 2 Comments